National Ph.D. Meeting
Salerno • 7-9 April 2016
Thursday, 7 April |
|
|---|---|
| 12:00 | Registration |
| 13:00-14:30 | Lunch Buffet |
| Session 1: Cell Biology Chairs: F. Innocenti and A. Margiotta |
|
| 15:00-15:30 | Luca Simula (Rome) Mitochondrial dynamics during T cell development and functions |
| 15:30-16:00 | Francesca Zappa (Naples) Stress granules control the secretory pathway by transiently sequestering Sar1 |
| 16:00-16:30 | Milena Vitale (Milan) Dynamics of endoplasmic reticulum stress responses to proteostatic challenges |
| 16:30-19:30 | Poster Session I (even numbers) [with coffee] |
| 19:30-20:30 | Keynote Lecture Chair: F. Innocenti Gabriella Minchiotti (Naples) Extrinsic regulation of stem cell metastability: learning from development and beyond |
| 20:45 | Dinner |
Friday, 8 April |
|
|---|---|
| Session 2: Cancer Biology Chairs: K. Lisek and M. Sciortino |
|
| 8:30-9:00 | Sara Beji (Rome) The nucleolar protein Nucleophosmin is rapidly secreted by cardiac progenitor cells in response to chemotherapics and mediates the intracellular uptake of miRNAs |
| 9:00-9:30 | Bartolo Bono (Pavia) Tumorspheres from in vitro transformed cell lines show deregulation of tumor-related molecular pathways |
| 9:30-10:00 | Francesca Bisceglia (Rome) Liver enriched transcription factors insensitive to tumor microenvironment as new therapeutic tools for hepatocellular carcinoma |
| 10:00-10:30 | Andrea Conte (Naples) HMGA1 over-expression induces chromosome instability through deregulation of spindle assembly checkpoint genes in cancer cells |
| 10:30-11:00 | Coffee break |
| 11:00-11:30 | Annamaria Salvati (Castel San Giorgio, SA) Impact of the histone methyl transferase DOT1L on estrogen signaling in breast cancer |
| 11:30-12:00 | Giuseppe Gritti (Bergamo) Effect of L-asparaginase in T-cell non-Hodgkin lymphoma: a preclinical study |
| 12:00-13:00 | Keynote Lecture Chair: M. Sciortino Letizia Lanzetti (Candiolo, TO) Endocytosis in cell division and migration |
| 13:00-14:30 | Lunch Buffet |
| 15:00-18:00 | Poster Session II (odd numbers) [with coffee] |
| Session 3: Cell migration and invasion Chairs: A. Margiotta and M. Sciortino |
|
| 18:00-18:30 | Martina Zobel (Milan) Spatial regulation of signaling by the endocytic protein Numb |
| 18:30-19:00 | Jacopo Dolcini (Ancona) LSD1 central role in setting the threshold of repression and activation of TGFβ1 regulated genes in EMT |
| 19:00-19:30 | Mario Tirone (Monza) The role of Endothelial-Mesenchymal Transition in physiological and pathological process |
| 19:30-20:30 | Keynote Lecture Chair: A. Margiotta Stefano Piccolo (Padua) Emerging technologies: organoids and stem cells YAP/TAZ in stem cells and tissue regeneration |
| 20:45 | Dinner |
Saturday, 9 April |
|
|---|---|
| Session 4: Molecular Medicine Chairs: F. Innocenti and K. Lisek |
|
| 9:00-9:30 | Rosa Bartolomeo (Pozzuoli, NA) Exploiting the cross-talk between lysosome and mTORC1 during bone development in lysosomal storage disorders |
| 9:30-10:00 | Francesca Zanetta (Pavia) The mitochondrial-driven oxidative stress induces the chronic activation of ATM-dependent DNA damage response in a Parkinson's disease cell model system |
| 10:00-10:30 | Samantha Ruberti (Modena) Role of c-MAF-induced inflammatory mediators in PMF pathogenesis |
| 10:30-11:00 | Coffee break |
| 11:00-11:30 | Eliana Trapani (Orbassano, TO) Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1 |
11:30-12:00 | Dominga Fasano (Naples) Fig4 regulates the homeostasis of endosomal compartments |
| 12:00 | Prizes for best oral presentation (Luca Daveggio award) and best posters |
The poster's maximum size is A0 (841 x 1189 mm; width x height).
Correct format... 
Wrong format...
You are expected to have your poster up the latest by 16:30 of Thursday, 7 April. Posters should be taken down at the end of the last poster session on Friday, 8 April, the latest before dinner. Posters left behind will be removed and discarded by the venue personnel.
P.1 Oriella Andresini (Rome) The Long non coding RNA kcnq1ot1 participates in the regulation of p57 expression during muscle cell differentiation |
P.3 Ilenia Aversa (Catanzaro) The silencing of the Ferritin heavy subunit constitutively activates CXCR4/CXCL12 axis |
P.5 Elisa Barbieri (Milan) Novel EGFR endocytic pathway requires calcium release at ER-PM contact sites |
P.7 Stefania Belli (Naples) Analysing tumor-stroma crosstalk through the application of a novel 3D Organotypic invasion assay |
P.9 Flavia Bernardi (Rome) Itch-dependent K63-polyubiquitylation of SuFu controls Hedgehog pathway and medulloblastoma tumorigenesis |
P.11 Serena Bianco (Turin) Purinergic signaling effect on cross talk between vascular endothelial and breast cancer cells |
P.13 Francesca Bufalieri (Rome) ERAP1 is a novel drug target in the oncogenic Hedgehog signaling pathway |
P.15 Nicolò Caporale (Milan) Human cerebral spheroids for studying neurodevelopmental effects of endocrine disruptive compounds exposure |
P.17 Manuel Caputo (Trieste) DEPDC1 promotes tumor aggressiveness modulating lipid metabolism |
P.19 Nando Cervone (Naples) Structural requirements for Fcp1 phosphatase mitotic function |
P.21 Alessandra Maria Adelaide Chiotto (Turin) Cell-autonomous vs non cell-autonomous cortical defects in a mouse model of Down Syndrome |
P.23 Sonia Ciotti (Udine) Identification and characterization of new genes regulating a proteotoxic-dependent necrotic cell death |
P.25 Valeria Colicchia (Rome) The poly (ADP-ribose) polymerase inhibitor olaparib causes mitotic catastrophe in MYCN amplified neuroblastoma by enhancing replication stress |
P.27 Katia Corano Scheri (Rome) c-Met proto-oncogene in testicular germ cell tumours |
P.29 Floriana Cremasco (Milan) SQSTM1/p62 sustains Blimp1 and plasma cell differentiation |
P.31 Marco D'Agostino (Rome) Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS |
P.33 Elisa De Paola (Rome) Role of the RNA helicase A (RHA) and its interaction with EWS-FLI1 oncogene in Ewing Sarcoma |
P.35 Maria Chiara De Santis (Turin) PI3KC2α, a new spindle associated protein involved in genomic instability and tumorigenesis. |
P.37 Giulia Dell'Omo (Milan) The oscillatory expression of ERα as a new drug target for resensitizing hormone-refractory breast cancer |
P.39 Daniela Di Girolamo (Naples) A reciprocal thyroid hormone-microRNA21 interplay refulates hedgehog pathway-driven skin tumorigenesis |
P.41 Giulia Di Marco (Padua) Role of mitoKATP in skeletal muscle |
P.43 Anthea Di Rita (Rome) Modulation of Serine 1014, flanking the LC3-Interacting region of AMBRA1, determines its mitophagic activity |
P.45 Valentina Esposito (Rome) In vitro study of human and mouse Leydig cell function |
P.47 Mario Failli (Pozzuoli, NA) SYStems biology of MEmbrane Trafficking SYSMET |
P.49 Ilaria Favicchia (Ercolano) Cellular and molecular origins of cortical defects in a mouse model of 22q11.2 deletion syndrome |
P.51 Simona Feno (Padua) Physiological role of the MCU dominant-negative subunit MCUb |
P.53 Giovanni Giangreco (Milan) Epsin3 role in mammary gland and tumorigenesis |
P.55 Francescopaolo Iavarone (Naples) Unraveling the inflammatory cells contribution of Cripto to skeletal muscle regeneration |
P.57 Kamil Lisek (Trieste) Activation of proteasome machinery by NRF2/mutant p53 axis and its therapeutic implications triple negative breast cancer |
P.59 Elisa Magistrati (Milan) Myosin VI, centrosome and primary cilium: a new connection to explore |
P.61 Sara Mancinelli (Naples) Impairment of neural fate in Cripto overexpressing neural stem cells |
P.63 Martina Mandruzzato (Busto Arsizio, VA) DNMT3A is required for reversible epithelial to mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells |
P.65 Marianna Martella (Rome) The translational control of p53 by eIF5A |
P.67 Maria Chiara Masone (Pozzuoli, NA) The role of the PI(4)P binding protein FAPP1 at the Golgi complex |
P.69 Nunzia Mollo (Naples) Potential therapeutic targets to restore mitochondrial function in Down syndrome |
P.71 Michela Napolitano (Naples) Diagnosis and classification of B cell acute lymphoblastic leukemia by Raman spectroscopy |
P.73 Valeria Noce (Rome) Role of mechanical stimuli and mechano-sensor YAP in hepatocyte differentiation |
P.75 Matteo Pagliari (Padua) MiRNA modulation in Helicobacter pylori-associated inflammation |
P.77 Silvia Palmerio (Rome) Role of Nucleophosmin in angiogenesis and tissue repair |
P.79 Emilia Pascale (Naples) Control of Pluripotency and Cell Lineage Determination Mediated by a transcribed Ultra-Conserved non-coding RNA in Embryonic Stem Cells |
P.81 Alessandra Perfetti (San Donato Milanese) Skeletal muscle and circulating microRNAs in myotonic dystrophy type 1 |
P.83 Mariasole Perrone (Ferrara) Role of PML tumorsuppressor in NLRP3 inflammasome activation |
P.85 Maria Rosaria Pricolo (Naples) Altered pre-mRNA splicing caused by novel intronic mutations in sarcomeric genes |
P.87 Abrar Rizvi (Milan) Elucidating the mechanism underlying the vascular defects due to genetic perturbation of EPS8 and IRSp53 |
P.89 Sebastiano Rontauroli (Modena) SOCS6 downregulation mediated by miR-494-3p supports megakaryocytopoiesis in normal and PMF CD34+ cells |
P.91 Claudia Russo (Naples) Mutations in the carboxyl terminal domain of p63 causative of AEC syndrome lead to protein aggregation and reduced DNA binding |
P.93 Luigi Sbano (Ferrara) Analysis of the contribution of lysosomes in intracellular calcium homeostasis |
P.95 Marianna Sciortino (Turin) New Blimp1 role in p130Cas/ErbB2 invasive breast cancer |
P.97 Assunta Sellitto (Baronissi, SA) Piwi-interacting RNAs (piRNAs) as novel biomarkers in cancer |
P.99 Olga Tarasiuk (Novara) Protein disulfide isomerase in ovarian cancer: a novel tumor-associated antigen and a potential target for cancer immunotherapy |
P.101 Aldo Tocci (Trieste) Characterization of Vitis vinifera chromatin domains via Hi-C sequencing |
P.103 Roberta Valsecchi (Milan) HIF-1α regulates the interaction of Chronic Lymphocytic Leukemia cells with the tumor microenvironment |
P.105 Valentina Zamboni (Turin) Disruption of ArhGAP15 affects the architecture and function of hippocampal inhibitory network, leading to enhanced activity, loss of synchronicity and cognitive deficits |
P.2 Costanza Angelini (Turin) p140Cap and Synaptic Plasticity through the interaction with NMDA receptor |
P.4 Rosario Avolio (Naples) Identification of TRAP1 and TRAP1-interacting protein Syndesmos as two novel, non canonical, RNA binding proteins |
P.6 Francesca Belardinilli (Rome) Validation of the Ion Torrent PGM sequencing for the prospective routine molecular diagnostic of colorectal cancer |
P.8 Cristina Bellisai (Rome) Localization of LINE-1 retrotransposition events in tumorigenesis and early embryogenesis |
P.10 Stefano Bestetti (Milan) Stress impairs H2O2 transport to impact cells fate |
P.12 Simone Brusco (Milan) Heteromeric nicotinic receptors in brain development and implications for sleep-related epilepsy |
P.14 Simona Buracco (Orbassano, TO) Dissecting iron homeostasis in the model organism Dictyostelium discoideum: Nramp divalent metal transporters and mitochondrial frataxin |
P.16 Marisa Cappella (Rome) An in vitro model to understand the role of microRNAs in Myotonic dystrophy type 1 |
P.18 Simona Cataldi (Naples) Defective adipocyte differentiation beyond genetic mutation: regulation of PPARγ through alternative splicing |
P.20 Jennifer Chapelle (Turin) p140Cap protein counteracts ERBB2-dependent Rac signaling in breast cancer cells |
P.22 Maria Elena Cicardi (Milan) Amyotrophic lateral sclerosis related proteins are actively removed by HspB8 |
P.24 Claudia Cirotti (Rome) ATM-Chk2 signaling cascade induces SOD1 nuclear translocation and S-nitrosoglutathione reductase (GSNOR) expression in response to oxidative stress |
P.26 Mafalda Concilli (Pozzuoli, NA) Proteomics reveals new target for correction of Wilson disease-causing ATP7B mutant |
P.28 Mariangela Corricelli (Ferrara) Role of Src kinase in the regulation of calcium homeostasis |
P.30 Valentina Cutano (Udine) Defining the role of the histone deacetylase HDAC7 in epithelial cell proliferation and morphogenesis |
P.32 Alberto Danese (Ferrara) Pathological mitophagy and disrupted mitochondrial homeostasis in Leber’s hereditary optic neuropathy |
P.34 Mariarosaria De Rosa (Naples) DNA oxidation drives estrogen-induced transcription |
P.36 Marco De Zuani (Udine) Cooperative effects of bacterial bioproducts and fungi on mast cell activation |
P.38 Federica Dellera (Milan) MicroRNA expression profiles of tissues involved in cholesterol metabolism from athero-prone and athero-resistant mouse models |
P.40 Luca Di Leo (Rome) Dehydroepiandrosterone mediates autophagic cell death via the JNK/Nrf2-mediated expression of p62/SQSTM1 in human hepatoma cell line HepG2 |
P.42 Sara Di Persio (Rome) Pro-inflammatory cytokine TNF-a regulates GDNF levels in Sertoli cells |
P.44 Daniela Esposito (Naples) Identification and functional characterization of a new long non-coding RNA antisense to MET oncogene |
P.46 Paola Fabbrizio (Rome) Clemastine confers neuroprotection and induces an anti-inflammatory phenotype in SOD1G93A mouse model of amyotrophic lateral sclerosis |
P.48 Elvira Famulari (Turin) Cell therapy for Crigler-Najjar type I syndrome using human adult liver stem cells |
P.50 Giorgia Federico (Naples) Ncoa4 protein couples DNA replication origin activation with cellular iron levels |
P.52 Angela Filograna (Naples) Investigating lipid droplets biogenesis: the role of CtBP1/BARS |
P.54 Valentina Iannizzotto (Rome) Exploring the SIRT1/c-Abl signaling network in genotoxic stress conditions |
P.56 Federica Innocenti (Rome) Effect of adrenocortical carcinoma treatment on fertility |
P.58 Filippo Macchi (Busto Arsizio, VA) UHRF1 interplay between DNA methylation and histone PTMs may lead to a severe chromatin modifications rearrangement in colon cancer |
P.60 Biagina Maimone (Milan) Role of miR-210 hypoxamiR in the angiogenic response following ischemia |
P.62 Barbara Mandriani (Brescia) Identification of p53-target genes in Danio rerio |
P.64 Azzurra Margiotta (Lecce) Rab7a regulates cell migration through Rac1 and vimentin |
P.66 Chiara Martino (Palermo) The toxic effect of gadolinium ions on sea urchin embryos: comparison among phylogenetically distant species and focus on mechanisms regulating stress response and skeletogenesis |
P.68 Marco Meroni (Milan) TGFb1 role in ALS muscle and motorneuron degeneration |
P.70 Claudia Morganti (Ferrara) PML KO impaired adipogenic differentiation and fat accumulation through selective autophagy |
P.72 Chiara Nicoletti (Modena) Comparison of computational methods for the analysis of Hi-C data |
P.74 Silvia Nuzzo (Naples) Therapeutic targeting of glioma stem cells by aptamer-miRNA/antimiR chimeras |
P.76 Gianmarco Pallavicini (Turin) Study of citron kinase as a possible therapeutic target for medulloblastoma |
P.78 Mariafranca Panebianco (Catanzaro) FHC gene silencing protects K562 cells against H2O2-induced stress via miR-21 up-regulation |
P.80 Anna Pepe (Naples) Lipid rafts perturbation and proteasomal block exacerbate “scrapie-like” properties of PrP-like protein Shadoo in cultured neuronal cells |
P.82 Francesca Marta Perrone (Catanzaro) DJ1 as a novel biomarker in the differential diagnosis between subtypes of endometrial cancer |
P.84 Emanuela Pone (Naples) Dissection of the autocrine IL-8-CXCR1/CXCR2 circuit in thyroid cancer stem cells |
P.86 Lorena Quirico (Turin) miR-148b and miR-214 as putative therapeutic targets |
P.88 Stefania Rocca (Turin) ROCK as therapeutical target for Morganalow aCML |
P.90 Chiara Rossi (Modena) Role of miR-382-5p/MXD1 axis in normal hematopoiesis |
P.92 Rossana Saracino (Rome) Regulation of the spermatogonial niche derived factor GDNF by retinoic acid |
P.94 Irene Schiano Lomoriello (Milan) A novel role of the endocytic protein Epsin 3 in breast tumorigenesis through regulation of mammary epithelial stem cells |
P.96 Anna Scotto Rosato (Pozzuoli, NA) MCOLN1: A New Terapeutic Target to Treat Lysosomal Storage Disorders |
P.98 Gaetano Sodaro (Naples) ZNF224 role in the regulation of Axl and Imatinib induced apoptosis of chronic myelogenous leukemia cells |
P.100 Sara Terreri (Naples) Expression and functional characterization of ultraconserved non-coding regions 339+ in development and cancer |
P.102 Patrizia Tornabene (Pozzuoli, NA) Three-dimensional retinal culture to model human inherited diseases |
P.104 Annalisa Verrico (Rome) Importin beta: a "moonlighting" transport factor with roles in mitosis, genetic instability and cancer |
The ABCD annual Ph.D. meeting is a yearly event completely devoted to Ph.D. students and co-organized by them. During the meeting, more senior students communicate orally their thesis project, while junior students display posters for lively discussions and general appraisal.
The meeting serves a dual function: it gives students the unique opportunity to exchange data and thoughts with their peers and is an ideal setting to get your project appraised by dedicated senior scientists.
Two-three prestigious scientists, chosen and invited by the students, give informal lectures and sit with the students during free time. This year the keynote speakers, proposed by the Ph.D. students’ committee are Gabriella Minchiotti from Naples and Letizia Lanzetti from Turin and a Lecture on Emerging Technologies about “ORGANOIDS and STEM CELLS” will be delivered by Stefano Piccolo.
A selection committee comprising students and senior scientists awards with a voucher the best poster and oral communication.
Gabriella Minchiotti is CNR Senior Scientist at the Institute of Genetics and Biophysics “A. Buzzati-Traverso” in Naples. She received her PhD in Molecular and Cellular Genetics from the University of Naples Federico II, studying the molecular mechanisms involved in the transcription of LINEs in Drosophila melanogaster. During her post-doctoral studies she became interested in cell differentiation and embryo development, which took her in the field of stem cells. She has worked in National and International Research Centers, such as the European Institute of Oncology (IEO) in Milan, the Ecole Normale Superieure in Paris and the Flander Institute for Biotechnology (VIB) in Lueven, Belgium, enriching her developmental and cell biology background. In 1998 she became CNR Researcher at the Institute of Genetics and Biophysics “A. Buzzati-Traverso” and since 2004 she is Group Leader of the Stem Cell Differentiation Unit and co-founder and co-coordinator of the Stem Cell Fate Laboratory at the same Institute. In 2007 she was appointed CNR Senior Scientist. Her current research focuses on the molecular basis of pluripotency and differentiation of stem cells. Her main interest is to understand how to direct stem cell differentiation along specific pathways and to develop molecular tools to target tumour initiating cells. More recently, her research interest is also focused on skeletal muscle stem cells and skeletal muscle regeneration, assessing the potential therapeutic value of the Cripto protein in alleviating muscle disease.
Assistant Professor in Biochemistry, Department of Oncology, University of Torino.
Group Leader, Membrane Trafficking Laboratory, Institute for Cancer Research and Treatment, Candiolo, Torino.
I obtained my degree in Biological Sciences at the University of Torino in 1995. My initial training was at the Department of Medical Genetic in Torino in the laboratory of Nicola Migone where I participate to the isolation and genetic characterization of a novel family of human genes encoding the endophilins. In 1997 I joined the laboratory of Pier Paolo Di Fiore at the Europen Institute of Oncology in Milan where I studied the biological function of the RN-tre protein. Initially, I identified this molecule as a GTPase-activating protein (GAP) for the endocytic small GTPase Rab5. Next I investigated the role of Rab5 and its GAP in signaling and in actin cytoskeleton remodeling.
By studying the function of RN-tre, we first realized that endocytosis was deeply linked to the signal transduction cascade being able to control the duration and the extent of the signal.
In 2008 I was awarded with a START UP grant from AIRC that allowed me to establish my own laboratory at the Institute for Cancer Research and Treatment in Candiolo, Torino. Within the START UP program, my group developed two major lines of research: we studied the involvement of endocytic proteins in cell division, revealing a novel function of Rab5 in mitosis, and we identified the molecular mechanism that, by regulating Rab5-mediated endocytosis of the integrin receptors, controls cell adhesion and polarized cell migration.
During these years my work has led to the identification of molecular pathways that control signaling and trafficking of receptors involved in cell transformation and in invasion.
Stefano Piccolo unveiled new mechanisms by which cells sense their environment and use this information to build and maintain tissues with specific form, size and function. Dr Piccolo also showed how disruption of these homeostatic mechanisms leads to tumor formation, progression and metastasis. Current main research topics are on Mechanotransduction, Wnt and Hippo pathways and how these signals regulate adult stem cells and cancer stem cells.